For full bibliography, please visit: https://pubmed.ncbi.nlm.nih.gov/?term=pacold+me&sort=date
Banh RS, Kim ES, Spillier Q, Biancur DE, Yamamoto K, Sohn ASW, Shi G, Jones DR, Kimmelman AC, Pacold ME. The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway. Published 1st September 2021.
Banh RS, Biancur DE, Yamamoto K, Sohn ASW, Walters B, Kuljanin M, Gikandi A, Wang H, Mancias JD, Schneider RJ, Pacold ME, Kimmelman AC. Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer. Cell. 2020 Nov 25;183(5):1202-1218.e25. doi: 10.1016/j.cell.2020.10.016
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL. Rapid Purification of Metabolic Profiling of Synaptic Vesicles from Mammalian Brain. Elife. 2020 Oct 12;9:e59699. doi: 10.7554/eLife.59699
https://pubmed.ncbi.nlm.nih.gov/33043885/
Wu L, Hollinshead KER, Hao Y, Au C, Kroehling L, Ng C, Lin WY, Li D, Silva HM, Shin J, Lafaille JJ, Possemato R, Pacold ME, Papagiannakopoulos T, Kimmelman AC, Satija R, Littman DR. Niche-Selective Inhibition of Pathogenic TH17 Cells by Targeting Metabolic Redundancy. Cell. 2020 Aug 6;182(3):641-654.e20. doi: 10.1016/j.cell.2020.06.014
https://pubmed.ncbi.nlm.nih.gov/32615085/
Ngo B*, Kim E*, Osorio-Vasquez V*, Doll S, Bustraan S, Liang R, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Kang D, Ni J, Plasger A, Rajasekhar VK, Kastenhuber ER, Eskandari R, Bacha S, Siriam RK, Stein BD, Bakhoum SF, Snuderl M, Cotzia P, Mainolfi N, Suri V, Friedman A, Manfredi M, Sabatini DM, Jones D, Yu M, Zhao JJ, Jain RK, Davies MA, Vander Heiden MG, Hernando E, Mann M, Cantley LC**, Pacold ME**. Limited Environmental Serine/Glycine Drives Brain Metastasis Metabolic Adaptation and Dictates Sensitivity to PHGDH Inhibition. Cancer Discov. 2020, 10: 1352-1373. DOI: 10.1158/2159-8290.CD-19-1228
*Co-first authors, **Co-corresponding authors
Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJYM, Possemato R, Fiske BP, Cho SW, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung HY, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, and Sabatini DM. A phosphoglycerate dehydrogenase inhibitor reveals coordination between serine synthesis and one-carbon unit utilization. Nature Chemical Biology, 2016, 12: 452-458
Saxton RA, Knockenhauer KE, Wolfson RL, Chantranupong L, Pacold ME, Wang T, Schwartz TU, and Sabatini DM. Structural basis for leucine sensing by the Sestrin-mTORC1 pathway. Science 2016, 351: 53-58
Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature 2015, 520: 363-367